STATISTICAL ASSESSMENT OF DRUG RELEASE KINETICS AND FORMULATIONS ATTRIBUTES OF RANITIDINE TABLETS AVAILABLE IN KARACHI, PAKISTAN

Abstract

In developing nations pharmaceutical formulations of same drugs may vary in their quality points of view. Such moieties offer elective decisions in individual social insurance deliverance setups with uneven estimating. Legitimizations of such items for treatment decisions are basically privileged of medication information gave by the maker and generally endure correlation points of interest of multisource items. Moreover drug release profiles of oral tablets likewise fundamentally essential in deciding the product unwavering quality in batch to batch framework. These investigations guarantee the items magnificence by observing distinctive products with equivalent remedial moieties. In the present study quality assessment including range of physic-chemical parameters was calculated for selected (six) brands of ranitidine (RT-1 to RT-6). Results were observed to be in satisfactory points of confinement. Additionally, disintegration profiles of all brands were resolved utilizing phosphate cradle pH 6.8. Information was investigated by a few factual strategies as recommended by FDA, for example, similarity factor (f₂) and difference factor (f₁) and one way ANOVA technique. Consequences of one – way ANOVA showed no huge distinction among the dissolution profiles of reference and test brands. Correspondingly, results of f₁ and f₂ showed similar profiles of test and reference products. In addition all the brands were found to be best fitted in Weibull model.