Harnessing the Healing Power of Java Plum (Syzygium Cumini) in an Animal Model: A Study on the Effects Against Neuroinflammation

A study on the effects against Neuroinflammation

Abstract

Objective: This study aims to evaluate and compare the anti-inflammatory, antidepressant, and anxiolytic effects of Syzygium cumini (Java plum) pulp and leaf extracts in rodent models, providing evidence-based insights into their neurotherapeutic potential.
Methodology: Adult rodents models (mice and rats) were used in established behavioral and inflammatory
models. The Forced Swim Test (FST) assessed antidepressant activity, the Elevated Plus Maze (EPM) tested
anxiolytic effects, and the Paw Edema test evaluated anti-inflammatory properties. Syzygium cumini pulp
and leaf extracts both were administered for comparison of their effects.
Results: Both pulp and leaf extracts showed significant anti-inflammatory effects in the Paw Edema test. The
pulp extract reduced immobility time in the FST, indicating antidepressant activity, and exhibited anxiolytic
effects in the EPM. The leaf extract only showed anti-inflammatory effects.
Conclusion: This research provides substantial evidence that the pulp extract of Syzygium cumini has
multifunctional neurotherapeutic potential and is effective in managing neuroinflammation and related mood
disordersÊin animal models. The leaf extract, on the contrary, possesses only anti-inflammatory properties.
These results demonstrate thatÊpulp extract isÊa natural option for creating advanced treatments for mood
and neuroinflammatory disorders. Further pharmacological and clinical studies are needed to explore its
standardize dosage, as well as assess the long-term effectiveness.