Association of Elevated Oxidized Low Density Lipoprotein to Low Density Lipoprotein Ratio (Ox LDL/LDL) with Sub Clinical Atherosclerosis in Patients Receiving Maintenance Haemodialysis

Sadia Rehman; Santosh Kumar; Kashif Nisar; Zara Sami; Fatima Mehboob; Suniya Rehman

doi:10.46663/ajsmu.v8i1.30-35

Sadia Rehman Bahria University Medical and Dental College
Santosh Kumar Jinnah Sindh Medical University, Karachi
Kashif Nisar Liaquat National Hospital and Medical College
Zara Sami Bahria University Medical and Dental College
Fatima Mehboob Pak Red Crescent Medical College, Lahore
Suniya Rehman Sir Ganga Ram Hospital, Lahore Pakistan

DOI: https://doi.org/10.46663/ajsmu.v8i1.30-35

Keywords: Hemodialysis, lipid peroxidation, oxidative stress, oxidozed LDL

Abstract

Objective: To assess the oxidized low density lipoprotein (ox-LDL) to low density lipoprotein (LDL) ratio as an indicator of subclinical atherosclerosis in haemodialysis patients
Methodology: This case control study was carried out at Jinnah Post Graduate Medical Center Karachi, from January to December 2018. The haemodialysis patients were selected from the dialysis center (group B) whereas the controls were recruited from normal healthy population (group A). To access the status of atherosclerosis, doppler ultrasonography technique was employed to detect the intima media thickness (IMT) ratio of common carotid artery of study subjects as well as controls. Lipid peroxidation was detected by serum oxidized LDL (ox-LDL) levels.
Results: The mean of carotid artery intima thickness in group A was 0.43±0.02, the mean intima thickness of group B samples was 1.0±0.09. The mean ratio of Ox-LDL/LDL in group A was 0.003±0.001. While in group B the mean of Ox-LDL: LDL was 0.012±0.002. Ox-LDL was found to have a positive linear relationship with mean carotid artery intima media thickness ratio (r=0.8) in haemodialysis group.
Conclusion: Ox-LDL to LDL ratio is much enhanced in patients on maintenance haemodialysis showing increased lipid peroxidation. Ox-LDL has a positive linear relationship with mean carotid artery intima media thickness ratio which is a marker of sub clinical atherosclerosis. Early detection of elevated Ox-LDL will help nephrologists in early detection and treatment of sub clinical atherosclerosis.

Author Biographies

Sadia Rehman, Bahria University Medical and Dental College

M.B.B.S., M.Phil (Biochemistry), Assistant Professor, Department of Biochemistry, Bahria University Medical and Dental College, Karachi

Santosh Kumar, Jinnah Sindh Medical University, Karachi

M.B.B.S, F.C.P.S. ( Nephrology), Assistant Professor, Jinnah Sindh Medical University, Karachi

Kashif Nisar, Liaquat National Hospital and Medical College

M.B.B.S, MPhil (Biochemistry), Professor, Department of Biochemistry, Liaquat National Hospital and Medical College, Karachi

Zara Sami, Bahria University Medical and Dental College

B.D.S. , PhD Scholar (Biochemistry), Senior Lecturer, Department of Biochemistry, Bahria University Medical and Dental College, Karachi

Fatima Mehboob, Pak Red Crescent Medical College, Lahore

M.B.B.S, M.C.P.S, D.P.H, D.D.M, DME, Professor of Medicine, Pak Red Crescent Medical College

Suniya Rehman, Sir Ganga Ram Hospital, Lahore Pakistan

M.B.B.S, M.C.P.S., Medical Officer, Sir Ganga Ram Hospital, Lahore

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